Nuno Espirito Santo's side took the lead after five minutes when a corner fell to Elliot Anderson on the edge of the area and his powerful deflected drive found the net.
Winning back-to-back titles for the first time since 1984 is likely to prove a rather more arduous challenge for Liverpool.
A stoppage-time finish from Rayan Cherki earned Olympique Lyonnais a dramatic 2-2 draw with Manchester United in the first leg of their Europa League quarter-final.
A round-up of Tuesday's action in the UEFA Champions League.
IMAGES from football matches played across Europe on Wednesday.
Barcelona will face a struggling Galatasaray team who are 13th in the Turkish top-flight.
A summary of Thursday's Europa League quarter-finals second-leg.
Eintracht Frankfurt changed their team shirt to display "#blacklivesmatter" on the front for their German Cup semi-final at Bayern Munich on Wednesday to take a stand against racism, the club said. Athletes across the world have joined in support of protests triggered by the death of unarmed black man George Floyd in US police custody last month.
United climbed to fourth in the standings on 15 points going into the last round of matches, in a strong position to reach the knockout phase along with Spurs who are sixth with 14 points.
Schalke 04 carried some of their Champions League momentum into the Bundesliga on Sunday, beating Freiburg 2-0 to bounce back after a string of erratic results.
A round-up of Thursday's Europa League Round of 16 second leg matches.
Qarabag had chances, Tural Baymarov missing from the penalty spot just before the hour mark and Junior hitting the woodwork, but Spurs stayed in control of the match.
Barcelona were shaken up by Eintracht Frankfurt but took a first step in their bid to reach the Europa League last four as a second-half goal by Ferran Torres salvaged a 1-1 comeback away draw in their quarter-final first leg on Thursday.
Manchester City spent more than 180 million pounds ($223.58 million) -- more than the combined amount paid by the other 19 English top-flight clubs in a relatively quiet window.
Manchester United breezed into the next round with a 6-1 aggregate win over Club Brugge
Kolo Muani replaces injured Nkunku in France's World Cup squad
Lazio, who had won all four previous games, were held to a frustrating scoreless draw by a Bulgarian side who came to defend.
Robert Lewandowski smashed home a rebound to earn Barcelona a 2-1 win against Athletic Bilbao in an absorbing LaLiga clash on Saturday.
IMAGES from Europa League matches played on Thursday.
Chelsea will face Dynamo Kiev at home in the first leg of their Europa League last-16 tie, while London rivals Arsenal will travel to Rennes following Friday's draw in Nyon, Switzerland.
Leaders Bayern Munich twice surrendered the lead in a 2-2 Bundesliga draw at 10-man Eintracht Frankfurt on Saturday and Borussia Moenchengladbach missed two penalties in a goalless draw against Hamburg SV.
A summary of Saturday's action in the LaLiga, Serie A and Bundesliga.
IMAGES from the Europa League matches played on Thursday
Bayern Munich crushed hosts Eintracht Frankfurt 4-0 with a superb display of attacking football on Wednesday to advance to the German Cup quarter-finals.
Bayern Munich stumbled to a 1-1 draw against visiting Eintracht Frankfurt on Saturday to leave them with only a slim Bundesliga lead after being held for the third game in a row with the same scoreline.
Bayern Munich defender Daniel van Buyten scored two minutes from time to give his team a 2-1 win over visitors Eintracht Frankfurt on Saturday and lift them to fifth place in the standings.
Forward Rasmus Hojlund scored twice to allow Manchester United to come back from a goal down and get a 2-1 win at six-times Czech champions Viktoria Plzen in the Europa League on Thursday.
Diego Costa's season is getting better and better. The Atletico striker found the net again and took the Madrid team atop the La Liga table.
Eintracht Frankfurt captain Marco Russ has been diagnosed with a tumour after he had initially tested positive in a routine doping test, the Bundesliga club said on Thursday.
Rediff.com brings you these and other exciting news from the week gone by in this photo feature...
Bayern Munich won their 22nd Bundesliga title in record time on Saturday by beating Eintracht Frankfurt 1-0 to open up an unassailable 20-point lead with six games left in the season.
Spain coach Luis Aragones announced a 23-man squad for next month's World Cup in Germany on Monday.
Bayern Munich can either move closer to three titles or miss out on them completely in the coming "weeks of truth", their coach Louis van Gaal said on Monday.
Bayer Leverkusen needed a second-half goal from defender Manuel Friedrich to earn a 1-1 draw with visitors Borussia Dortmund on Friday and move a point clear at the top of the Bundesliga.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Moritz Stoppelkamp scored an extraordinary goal from deep inside his own half, a Bundesliga record 83 metres, to cap a 2-0 win for upstarts Paderborn over Hanover 96 on Saturday, helping the promoted side go to of the table.
Standard had their professional licence rescinded on April 8 after the Belgian football association found they had not paid premiums owed to players.
IMAGES from the soccer matches played across leagues on Friday
Real have not lost any of their last six games against Liverpool in the Champions League
VfL Wolfsburg midfielder Kevin De Bruyne has been fined $22,644 for his foul-mouthed outburst at a ball boy.